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Index > Protein center > Pdcd1lg2(Gene name) > Mouse
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  • Pdcd1lg2 (Gene name),
  • Programmed cell death 1 ligand 2 (Protein name ),  PD1L2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Pdcd1lg2(B7dc;Btdc;Cd273;Pdl2);
    Protein name:
    Programmed cell death 1 ligand 2(PD-1 ligand 2;PD-L2;PDCD1 ligand 2;Programmed death ligand 2);
    Alternative:
    Butyrophilin B7-DC(B7-DC);
    CD:
    CD273;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with PDCD1.
    Function:
    Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    247
    Sequence:
    50:
    MLLLLPILNL | SLQLHPVAAL | FTVTAPKEVY | TVDVGSSVSL | ECDFDRRECT | 
    100:
    ELEGIRASLQ | KVENDTSLQS | ERATLLEEQL | PLGKALFHIP | SVQVRDSGQY | 
    150:
    RCLVICGAAW | DYKYLTVKVK | ASYMRIDTRI | LEVPGTGEVQ | LTCQARGYPL | 
    200:
    AEVSWQNVSV | PANTSHIRTP | EGLYQVTSVL | RLKPQPSRNF | SCMFWNAHMK | 
    247:
    ELTSAIIDPL | SRMEPKVPRT | WPLHVFIPAC | TIALIFLAIV | IIQRKRI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse PD-1 ligand 2
    Cat.:
    E8946h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse PD-1 ligand 2
    Cat.:
    E8946m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse PD-1 ligand 2
    Cat.:
    U8946h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse PD-1 ligand 2
    Cat.:
    U8946m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse PD-1 ligand 2
    Cat.:
    P8946Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse PD-1 ligand 2
    Cat.:
    P8946Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse PD-1 ligand 2
    Monoclonal Antibody for Mouse PD-1 ligand 2
    Protein for Mouse PD-1 ligand 2
    Protein for Mouse PD-1 ligand 2

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells."
      Tseng S.-Y. , Otsuji M. , Gorski K. , Huang X. , Slansky J.E. , Pai S.I. , Shalabi A. , Shin T. , Pardoll D.M. , Tsuchiya H.
      J. Exp. Med.193:839-846(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH PDCD1;TISSUE SPECIFICITY
      strain: BALB/c.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    4. 4.
      "Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction."
      Wang S. , Bajorath J. , Flies D.B. , Dong H. , Honjo T. , Chen L.
      J. Exp. Med.197:1083-1091(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ASP-33; SER-39; GLU-41; ARG-56; SER-58; ASP-65; SER-67; GLU-71; ARG-72; LYS-84; HIS-88; ARG-101; LEU-103; ILE-105; ASP-111; LYS-113 AND THR-116
    5. 5.
      "Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2."
      Lazar-Molnar E. , Yan Q. , Cao E. , Ramagopal U. , Nathenson S.G. , Almo S.C.
      Proc. Natl. Acad. Sci. U.S.A.105:10483-10488(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 1-220 IN COMPLEX WITH PDCD1;DISULFIDE BOND
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